Sr. Research Investigator Quantitative Clinical Pharmacology - Quantitative Systems Pharmacology

Profile

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Summary:

The Quantitative Clinical Pharmacology (QCP) group within Clinical Pharmacology & Pharmacometrics (CP&P) is searching for a scientist with expertise in Quantitative Systems Pharmacology (QSP). The QSP Scientist will develop and apply Quantitative Systems Pharmacology (QSP) models to address drug-discovery and development questions in the Immunology disease area. QSP models are mathematical models that are used to integrate knowledge and data on disease pathophysiology and drug pharmacology in a mechanistic manner. This enables hypothesis generation and testing in target discovery, translational pharmacology and clinical drug development.

Position responsibilities include:


Developing and applying Quantitative Systems Pharmacology (QSP) models to address drug-discovery and development questions in the Immunology disease area
Providingleadership to and collaboration with multidisciplinary project teams to develop and applyQSP models to aid in target prioritization, therapeutic modality selection, chemical/biotherapeutic optimization, biomarker characterization and early clinical trial design
Partnering with external groups to accelerate the internal Systems Pharmacology efforts in key disease areas
Providing expert support to project teams for the design, execute and interpret clinical studies
Maintaining at the project level an active relationship with colleagues in Clinical Pharmacology & Pharmacometrics as well as in the advancement of Pharmacometrics
Network with stakeholders in Discovery Biology, Clinical Development, and Translational Medicine to facilitate model development and application
Align QSP model deliverables with the clinical pharmacology and clinical development plans
Leverage existing virtual population workflows and script-based analysis packages
Stay informed with emerging literature and science in the systems biology/pharmacology modeling and simulation sciences
Build and maintain a personal track record of publication in the area of QSP


Degree requirements:

Ph.D. in Engineering, Mathematics, Bioinformatics, Pharmacometrics, Systems Biology/Pharmacology or a related field

Experience Requirements

2 years of pharmaceutical industry experience, including significant experience in developing and applying QSP modeling to support translational and clinical research

Key Competency Requirements


Excellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation. Knowledge of process control theory would be beneficial
Good understanding of the basic principles of pharmacokinetics and pharmacodynamics
Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop QSP models
Ability to communicate internally and externally on topics related to CP&P and QSP is required
Ability to keep up to date with and propose the implementation of scientific and technological developments in the area of Systems Pharmacology/Biology
Hands-on experience with modeling software like Matlab/SimBiology/Simulink, JDesigner/Systems Biology Workbench, Entelos PhysioLab Platform, DBSolve, etc. Experience with Matlab SimBiology would be particularly desirable
Experience with general programming and data analysis tools/languages such as Python, R, Matlab, Spotfire, etc., is required
Desire to interact as a modeling and simulation expert across clinical development teams with experts from different functional areas (pre-clinical and clinical)
Experience working in one of BMS' disease areas of interest is desirable
Knowledge of current practices and issues in pharmaceutical R&D in disciplines such as clinical pharmacology, bioanalytical, biopharmaceutics, and toxicology


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol-Myers Squibb

Req Number: R1526963_EN

Updated: 2020-07-06 00:00:00.000 UTC

Location: Princeton,New Jersey

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

Company info

Sign Up Now - PharmaceuticalCrossing.com