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Pharmaceutical Jobs >> Pharmaceutical Articles >> Pharmaceutical Career Feature >> Synthetic Organic Chemistry Research Job
  • Pharmaceutical Career Feature

Synthetic Organic Chemistry Research Job


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Synthetic organic chemistry research is done by a scientist who independently designs, plans, and executes experiments for assessing and improving synthetic routes to APIs (an application programming interface, API is a set of routines, data structures, object classes, and/or protocols) in support of projects that are in preclinical development through early clinical development.

Here are some basic duties for a synthetic organic chemist research scientist:

With general guidance, organic chemist research scientists are responsible for designing and processing R&D services and preliminary scale-up services for drug discovery projects in order to advance those programs into preclinical development. This field is a great position for new grads with PhDs and some experience in organic synthetic chemistry.

Responsibilities:
  • Independently design, plan, and execute experiments for assessing and improving synthetic organic chemistry to APIs in support of projects that are in preclinical development through early clinical development.
  • Perform thorough process research and creative route scouting with the goal of route selection within aggressive timelines.
  • Independently solve synthetic problems of a moderate scope towards the goal of chemical process development.
  • Prepare gram to kilogram quantities of APIs, intermediates, impurities, reference standards, and support such activities at CROs.
  • Perform scale-up, purification, process optimization, technology transfer, and process validation activities.
  • Prepare tech transfer packages allowing larger-scale preparation.
  • Perform route development and optimization, standard preparations, and impurity elucidations.
  • Prepare technology transfer documents and provide/present project updates.
  • Develop novel and efficient process chemistry strategies and coordinate research strategies and activities with team members.
  • Acquire a current understanding of process chemistry literature and methodology, as well as the scientific literature related to the specific drug discovery project.
  • Keep an accurate, comprehensible, concise notebook in accordance with company policy.
  • Influence the course of projects.
  • With general guidance, learn standards and levels of expectations for routine work; design experimental strategies.
  • Learn company's discovery process.
  • Identify routine obstacles to progress; solve a variety of problems.
  • May mentor research associates.
  • Support at least one project of defined scope and moderate complexity.
  • Represent own research to senior leadership, or for scientific collaborations, or a national scientific conference.
Requirements:
  • PhD in Chemistry with thesis and publication(s) OR
  • MS in Chemistry with minimum of seven years' of relevant experience and distinguished publication record OR
  • BS in Chemistry with minimum of twelve years' relevant experience and distinguished publication record.
  • A solid understanding of synthetic organic chemistry.
  • A high level of proficiency carrying out multi-step syntheses.
  • Working knowledge of modern synthetic methods, spectroscopy, analytical techniques, and scale-up equipment.
  • Thorough experience in handling, synthesizing, purifying, and characterizing of complex organic molecules using the latest techniques.
  • Experience with route scouting as well as route optimization preferred.
  • Familiarity with project management tools.
  • Demonstrated independent thought/creativity in science.
  • Ability to convey ideas in an experimentally detailed yet scientifically concise manner.
  • Excellent communication and multitasking skills.
  • Expert knowledge of applicable lab equipment.
  • High degree of scientific discretion/intuition.
Synthetic organic chemistry research scientist positions are not for the faint of heart. They are positions which require much dedication. Much schooling and experience are required to become a research scientist. Research scientists are becoming a precious commodity with such opportunities to change business using the synthetic organic researchers at this time. The pharmaceutical industry has never had an economic crisis. So they lead the way in hiring researchers to continue to discover new ways to create generic medicine using synthetic organic chemistry to recreate a drug's original structures. This enables hundreds of new generic drugs to be put into the market at a better price than the original.


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