Senior Research Associate Viral Vector Process Development

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis. Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results

The Senior Research Associate will join our viral vector process development group supporting process development, production and characterization of viral vectors, which are key intermediates in the CAR-T drug product. The candidate will support current programs and advance our capabilities in vector production.

Job Description:

Responsibilities:


Hands-on experimental work in the development and optimization of upstream (cell culture and transfection conditions) and downstream (clarification, tangential flow filtration, chromatography) unit operations for viral vector production

Lead various aspects of the process development program for next generation viral vector manufacturing platforms

Problem solving and troubleshooting exist process designs, and technologies, using scaled-down models

Independently design experiments, using DOE principles followed by independent execution and analysis of data.

Maintain proper documentation of experimental results.

Lead process transfer, development and manufacturing activities internally or at external CMOs.


Basic Qualifications:


B.S. in Engineering, Virology, Biology, Biochemistry, or related discipline and 2-6 years of relevant experience

Demonstrated experience in the development of biological processes

Proven ability to design experiments with DoE approaches, execute DoE designs and interpret the results

Independently motivated with ability to work in teams

Ability to communicate clearly and concisely through oral presentation and technical writing


Preferred Qualifications:


Experience in the development of viral vectors (e.g. adeno-, retro-, lenti-), including successful transfer for GMP manufacturing

Operation/optimization of fixed-bed or stirred-tank bioreactors

Experience developing harvest processes for mammalian cell-culture processes

Experience interfacing with contract manufacturing and development organizations

Proven track record of high-quality external presentations and peer-reviewed publications

Experience in authoring regulatory documents, including IND and BLA submissions

Familiarity with basic analytical assay formats (e.g. ELISA, PCR, flow cytometry etc.) and ability to operate associated analytical equipment


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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