Senior Research Associate Molecular Engineering

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

The Immuno-Oncology and Cellular Therapy Thematic Research Center is one of the fundamental research and early development engines delivering therapeutics to patients. Our mission is to drive leadership in the use of immune effector cell-based therapies in hematological and solid cancers. More specifically, we are focused on developing engineered cell-based therapies, as well as biotherapeutics, both aimed at harnessing the power of immune cells to mediate anti-tumor activity. The team integrates discovery research seamlessly with preclinical sciences, translational research and early clinical development in collaboration with colleagues across the Research and Development organization. Our thematic focus allows the group to capitalize on the cutting edge science that underpins the action of many of the company’s most innovative therapeutics, without being constrained by drug modality or disease indication.

We are seeking an enthusiastic, self-driven Senior Research Associate who will help to design and build the next generation of chimeric antigen receptors (CARs). “Living drugs” such as CAR T cells are already revolutionizing cancer treatment, and our goal is to engineer the next generation of CARs that will expand the number of patients we are able to treat, and further improve outcomes for those receiving that treatment. The candidate will leverage our current understanding of CAR and T cell biology, as well as high-throughput sequencing data, to inform new engineering strategies, and will then use molecular biology and cell culture techniques to build these next-generation cell therapies and test their function.

People who would thrive in this position may not have all the skills listed in the responsibilities section, but will be enthusiastic about the project, interested in expanding their skill-set and knowledge base, and willing and able to learn new techniques.

Responsibilities include:

Design and build next-generation CAR and cell therapy constructs using plasmid map construction software and molecular biology cloning techniques

Generate lentivirus from these constructs and transduce cell lines and primary cells

Test these new constructs in cell lines and primary T cells using a variety of functional assays such as flow-cytometry, ELISA, in vitro cell killing, RNA-seq and ATAC-seq

Participate in interpretation of the results of these assays, and in planning follow-up experiments

Become familiar with primary literature to understand current issues facing the field and contribute new engineering solutions

Perform basic data analysis on NGS datasets using pre-developed analytical tools

Maintain meticulous records of cloning strategies, bench experiments, and data analyses

Undergo training in new techniques as the project evolves

Basic Qualifications:

BS or MS in molecular biology, genetics, bioengineering, or related field

2 years of molecular biology laboratory experience with plasmid design and cloning

Strong interpersonal skills

Experience with cell culture, primary cell culture experience preferred

Ability to analyze, interpret, and present scientific data in a clear manner

Strong organization, time management and problem-solving skills with attention to detail

Desire and ability to expand skill-sets at the bench and knowledge-base through independent reading and seeking out information from colleagues and collaborators

Preferred Qualifications:

Experience in plasmid construction software such as Geneious, Snapgene, or MacVector

Knowledge and experience with lentiviral vector biology

Experience preparing virus and transducing cells

Experience culturing and handling primary human cells, particularly human T cells

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

Company info

Bristol-Myers Squibb Company
Website : http://www.bms.com