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Job Details

Principal Scientist Medicinal Chemistry

Company name
Alkermes, Inc.

Waltham, MA, United States

Employment Type

Sciences, Scientist, Pharmaceutical, Chemistry

Posted on
Jan 04,2019

Valid Through
Apr 19,2019

Apply for this job


Alkermes plc is a fully integrated, global biopharmaceutical company developing innovative medicines for the treatment of central nervous system diseases. The company has a diversified commercial product portfolio and a substantial clinical pipeline of product candidates for chronic diseases that include schizophrenia, depression, addiction and multiple sclerosis. Headquartered in Dublin, Ireland, Alkermes plc has an R&D center in Waltham, Massachusetts; a research and manufacturing facility in Athlone, Ireland; and a manufacturing facility in Wilmington, Ohio. For more information, please visit Alkermes’ website at

Job Description:

As a senior medicinal chemist have the ability to drive compound design inside a chemistry team for a given project directed toward successful project progression and candidate drug delivery

Includes responsibility for setting and maintaining the highest scientific standards in drug design activities

Ensure an optimal level of engagement with all relevant disciplines e.g. chemistry, biology, DMPK, safety, etc.

Evaluates scientific or technical opportunities, while targeting optimal results

Seeks external benchmarks for functional excellence

Reaches beyond immediate knowledge to influence results

Determines next steps even with complex or ambiguous data

Help contribute and expand Alkermes’ culture of “hypothesis driven” science

Establishes consistency in solving complex, technical problems

Creates and tests complex hypotheses

Drives technical course of a project area

Demonstrates situational leadership and creative problem solving

Analyzes specific or unique situations and data, requiring in-depth evaluation

Be a scientific and strategic resource for local chemistry management as relates to new ways of working in medicinal chemistry

Drive progress and implement improvements in medicinal chemistry for the design and delivery of candidate drugs

Ensure robust hypotheses for all proposed molecules

Work closely with computational chemistry to implement relevant predictive models to aid in the design of new compounds

Explore new applications for data analysis to assist in hypothesis driven compound design

Foster a close collaboration with synthetic chemistry to enhance design through synthesis

As chemistry lead, assist project leader in the development of strategic, scientific, and technical strategies for a given project

Initiate and manage external collaborations to enhance internal projects, capabilities and company recognition

Help drive relevant publications strategy and delivery

Successfully establish new projects and/or new scientific initiatives

Be a role model in behaviors for Alkermes’ way of working

Act in accordance with all Alkermes’ policies for personnel, EHS, etc.

Minimum Education & Experience Requirements:

A Ph.D. with at least 8 years’ pharmaceutical experience and an accomplished track record of delivery for drug discovery projects

Technical Expertise Requirements:

Recognized expert in modern medicinal and synthetic chemistry approaches and principles that contribute to successful delivery of drug discovery projects

Led programs that delivered compounds into the clinic

Lead author on scientifically reviewed publications

Presented at professional conferences

Managed chemistry teams of 4 or more people including Ph.D. scientists

Inventor on published patents

Understanding of overall drug discovery process and how to impact from medicinal chemistry perspective

Strong technical communication and collaboration skills

Effective leadership skills

Effective communication skills i.e. must have ability and judgment to communicate appropriate information

Able to propose and implement scientific ideas

Personal Attributes Needed:

Excellent interpersonal, leadership, communication, and time-management skills are essential

Alkermes, Inc. is an equal employment opportunity employer and does not discriminate against any applicant because of race, color, religion, sex, sexual orientation, gender expression and identity, national origin, ancestry, age, mental and physical disability, genetic information, any veteran status, military status or application for military service, or membership in any other category protected under applicable law.


Experience Level:

Mid-Senior Level



Company info

Alkermes, Inc.
Website :

Company Profile
Alkermes is a leader in innovative medicines that address the unmet needs and challenges of people living with debilitating diseases. As a fully integrated global biopharmaceutical company, Alkermes applies our scientific expertise, proprietary technologies, and global resources to develop products that are designed to make a meaningful difference in the way patients manage their disease.

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